Azithromycin

Active Ingredient: Azithromycin

$0.44 per pill Azithromycin as macrolides and generally refers to less toxic antibiotics. The overall incidence of side effects of azithromycin - about 9%.
 

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Azithromycin as macrolides and generally refers to less toxic antibiotics. The overall incidence of side effects of azithromycin - about 9% (using erythromycin - 30-40% of clarithromycin - 16%). The frequency of side effects of azithromycin, requiring discontinuation of the drug, an average of 0.8%.

A meta-analysis of studies conducted in Western Europe, North and South America, Africa and Asia, have shown that azithromycin is associated with a significantly lower incidence of adverse effects than the comparison drugs in the treatment of both adults and children (7.6% and 8 7% azithromycin, 9.8% and 13.8% for the other antibiotic). Premature discontinuation of treatment required in 0.1-1.3% of patients treated with azithromycin and at 1-2,6% of patients receiving comparators.

Azithromycin Security has also been studied in 46 studies conducted in Central and Eastern Europe.

They have been included 2650 adults and 1006 children treated with azithromycin and 831 adults and 375 children receiving erythromycin, roxithromycin, clarithromycin, midecamycin, josamycin, penicillin, amoxicillin, co-amoxiclav, cefaclor, ciprofloxacin or doxycycline. Unwanted effects have been observed in 5.3% of adults and 7.2% of children treated with azithromycin, 14.9% and 19.2% of adults and children who received the reference drugs. Premature discontinuation of treatment was required in 0.09% of adults and 0.4% of children treated with azithromycin and 2.3% of adults and 2.1% of children treated with other antibiotics.

The other 15 studies involved 1616 patients treated with azithromycin and 1613 patients treated with roxithromycin, clarithromycin, amoxicillin, co-amoxiclav or cefaclor. Adverse effects were noted in 10.5% of patients treated with azithromycin and 11.5% of patients treated with the reference drugs. Premature discontinuation of treatment was required in 0.4% of patients treated with azithromycin and 2.1% of patients receiving comparators.

In a clinical study of azithromycin tolerability conducted double-blind study in 2598 children, side effects were observed in 8.4% of patients. They were significantly more common in children who received a comparison drug (12.9%) - co-amoxiclav, ampicillin, penicillin, cephalexin, cefaclor, doxycycline, dicloxacillin, flucloxacillin, josamycin and erythromycin.

Gastro-intestinal adverse events occur in azithromycin in 6-9% of cases, clarithromycin - 12%, erythromycin - in 20-32%. In the treatment with azithromycin mild to moderate abdominal pain, nausea, vomiting or diarrhea were observed in 5% of children (when taking erythromycin and other 14-membered macrolides, which are stimulants motilinovyh receptors, diarrhea occurs much more frequently).

Hepatotoxicity is unusual for azithromycin, but perhaps in rare cases, long-term use josamycin, spiramycin, clarithromycin, and high doses of erythromycin.

Undesirable effects on the central nervous and cardiovascular systems, not heavy and occur in less than 1% of cases.

In contrast to the treatment of beta-lactam antibiotics, bacteria overgrowth and associated complications in the treatment of azithromycin uncommon because it, like other macrolides, has no effect on the normal intestinal microflora.

Allergic reactions to azithromycin

Allergic reactions to azithromycin and other macrolides are rare (less than 1% of cases) and generally is limited to cutaneous manifestations. At the same time they develop to penicillin in 10%, and cephalosporins - 4% of patients. Perekrestnaya allergic to penicillins and cephalosporins is absent, but noted perekrestnaya allergic to other macrolides.

Buy Azithromycin - is only contraindicated in case of hypersensitivity to macrolides, hepatic failure, in the first trimester of pregnancy (except in cases where the expected benefit to the mother outweighs the potential risk to the fetus) and during lactation.

Interaction at the level of biotransformation in the liver the most clinically significant for erythromycin oleandomitsina, clarithromycin and josamycin, to a lesser extent - for roxithromycin and midecamycin and uncharacteristically for azithromycin, dirithromycin and spiramycin. When using macrolides in patients taking concomitant medications that are metabolized by the cytochrome P-450 can slow down their elimination. This increases the concentration of drug in the serum and increased risk of side effects.

Thus, in particular, increased anticoagulant effect anticoagulants (warfarin, acenocoumarol, phenindione, ethyl biskumatsetata), nephrotoxic effects of immunosuppressants (cyclosporin and tacrolimus), increases the duration of glucocorticoid action, the risk of rhabdomyolysis is increased under the action of statins, the incidence of adverse effects disopyramide antagonists calcium (nifedipine and verapamil), bromocriptine, antiviral drugs used in HIV infection, hypnotics and anticonvulsants (carbamazepine, valproate, phenytoin), tranquilizers (midazolam, triazolam, zopiclone), increases plasma levels of cisapride, pimozide, antihistamines ( terfenadine, astemizole, ebastine).

This can lead to a lengthening of the QT interval on the ECG and cardiac arrhythmias including ventricular tachycardia, ventricular fibrillation, atrial flutter, or ventricular fibrillation. Macrolides (azithromycin and besides midecamycin) cause an increase in the concentration of theophylline in serum (10-50%), and theophylline toxicity.

Due to the fact that azithromycin is not an inhibitor of cytochrome P-450, it does not react with theophylline, hypnotics and anticonvulsants, tranquilizers, indirect anticoagulants, antihistamines. It is reliably confirmed in controlled studies specifically performed.

Buy Azithromycin: it is indicated for the monotherapy of acute bronchitis and bronchiolitis bacterial etiology

During exacerbation of chronic bronchitis azithromycin, thanks to the activity against Haemophilus influenzae is an alternative drug. When netyazhelom within community-acquired pneumonia, azithromycin belongs to first-line drugs for monotherapy. In the presence of clinical or epidemiological evidence of mycoplasma, Chlamydia and Legionella (atypical) pneumonia, it is the drug of choice. When tyazhelom during priem pneumonia azithromycin may supplement parenteral administration of beta-lactam antibiotics.

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